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2. Apoquel for Cats: Uses, Dosage, & Side Effects - AOL

   www.aol.com/lifestyle/apoquel-cats-uses-dosage...

   The post Apoquel for Cats: Uses, Dosage, & Side Effects appeared first on CatTime. Apoquel is a medication prescribed for pets — particularly dogs — to alleviate symptoms associated with ...

3. Dipeptidyl peptidase-4 inhibitor - Wikipedia

   en.wikipedia.org/wiki/Dipeptidyl_peptidase-4...

   DPP-4 inhibitors and GLP-1. Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006. [1]

4. Discovery and development of dipeptidyl peptidase-4 inhibitors

   en.wikipedia.org/wiki/Discovery_and_development...

   It used thiazolidide as the P1-substitute and was the first DPP-4 inhibitor that showed effects in both animals and humans but it was not developed to a market drug due to side effects. Another old inhibitor is DPP-728 from Novartis, where 2-cyanopyrrolidine is used as the P1-substitute. The addition of the cyano group generally increases the ...

5. Glucagon-like peptide-1 - Wikipedia

   en.wikipedia.org/wiki/Glucagon-like_peptide-1

   To overcome this, GLP-1 receptor agonists and DPP-4 inhibitors have been developed to increase GLP-1 activity. As opposed to common treatment agents such as insulin and sulphonylureas, GLP-1-based treatment has been associated with weight loss and a lower risk of hypoglycemia, two important considerations for patients with type 2 diabetes.

6. GLP-1 receptor agonist - Wikipedia

   en.wikipedia.org/wiki/GLP-1_receptor_agonist

   Another class of anti-diabetes drugs, DPP-4 inhibitors, work by reducing the breakdown of endogenous GLP-1, and are generally considered less potent than GLP-1 agonists. [3] Some of the metabolic effects of GLP-1 agonists in rodents are mediated via increased synthesis of fibroblast growth factor 21 . Pharmaceutical companies have developed ...

7. Vildagliptin - Wikipedia

   en.wikipedia.org/wiki/Vildagliptin

   Vildagliptin inhibits the inactivation of GLP-1 [2] [3] and GIP [3] by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas. It was approved by the EMA in 2007. [4]

8. Linagliptin - Wikipedia

   en.wikipedia.org/wiki/Linagliptin

   Linagliptin, sold under the brand name Tradjenta among others, is a medication used to treat type 2 diabetes (but not type 1) in conjunction with exercise and diet. [8] [9] It is generally less preferred than metformin and sulfonylureas as an initial treatment. [8] [10] It is taken by mouth. [8] Common side effects include inflammation of the ...

9. Top aging expert says these 4 FDA-approved drugs hold promise ...

   www.aol.com/finance/global-aging-doctor-says-4...

   New research also suggests the inhibitors may reduce the risk of dementia in people with type 2 diabetes after longer-term use. Bisphosphonates Bisphosphonates, scoring 11 out of 12, treat ...