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Howard Green (September 10, 1925 – October 31, 2015) was an American scientist, and George Higginson Professor of Cell Biology at Harvard Medical School. He was the first to culture human cells in a laboratory setting for therapeutic use. He is one of the founding fathers of stem-cell research and regenerative medicine.
This is an accepted version of this page This is the latest accepted revision, reviewed on 17 November 2024. American medical doctor and scientist Robert P. Lanza Lanza in 2009 Born Robert Lanza (1956-02-11) 11 February 1956 (age 68) Boston, Massachusetts, U.S. Nationality American Alma mater University of Pennsylvania Known for Stem cell biology, cloning, tissue engineering, biocentric ...
Working together, biologists James Till and Ernest McCulloch made contributions to stem cell research by demonstrating the existence of multipotent stem cells in 1961. They helped lay the foundation for modern stem cell biology and regenerative medicine through their work while studying the effects of radiation on the bone marrow of mice at the Ontario Cancer Institute in Toronto.
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
Cell replacement therapy with iPS cells is a possibility. Stem cells can replace diseased or lost cells in degenerative disorders and they are less prone to immune rejection. However, there is a danger that it may introduce mutations or other genomic abnormalities that render it unsuitable for cell therapy.
Haruko Obokata (小保方 晴子, Obokata Haruko, born 1983) is a former stem-cell biologist and research unit leader at Japan's Laboratory for Cellular Reprogramming, Riken Center for Developmental Biology.
They cemented their stem cell theory and in 1963 published their results in Nature. [2] In the same year, in collaboration with Lou Siminovitch , a trailblazer for molecular biology in Canada, they obtained evidence that these same marrow cells were capable of self-renewal, a crucial aspect of the functional definition of stem cells that they ...
Wnt-1 was later discovered to be a key player in the stem cell self-renewal pathway. [8] She joined the biotech company SyStemix from 1989 to 1997, [9] where she co-discovered the human hematopoietic stem cell (hHSC) and played a leading role in the launch of the clinical research program for this cell. The purified hHSC was shown to be cancer ...