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Tizanidine, sold under the brand name Zanaflex among others, is an alpha-2 (α 2) adrenergic receptor agonist, [2] similar to clonidine, that is used to treat muscle spasticity due to spinal cord injury, multiple sclerosis, and spastic cerebral palsy. [3] Effectiveness appears similar to baclofen or diazepam. [4] It is taken by mouth. [5]
Tizanidine was found to decrease the average frequency of headaches per week, the headache intensity, and the mean headache duration. [15] Through studies, Fluoxetine resulted in better mood ratings and "significant increases in headache-free days". [16]
Other skeletal muscle relaxants of that type used around the world come from a number of drug categories and other drugs used primarily for this indication include orphenadrine (anticholinergic), chlorzoxazone, tizanidine (clonidine relative), diazepam, tetrazepam and other benzodiazepines, mephenoxalone, methocarbamol, dantrolene, baclofen. [7]
The US Food and Drug Administration (FDA) considers it to be a first-in-class medication. [ 20 ] [ 21 ] It was approved by the FDA for weight loss in November 2023. [ 16 ] [ 22 ] In November 2023, the UK Medicines and Healthcare products Regulatory Agency revised the indication for tirzepatide (as Mounjaro) to include the treatment for weight ...
The company licensed tizanidine (Zanaflex) from Élan in the early 2000s to help meeting cash flow goals. [2] Acorda sells both capsule and tablet forms of this drug, with emphasis on the capsule form as this has patent protection through 2021, while the tablet form has many generic competitors. [2]
Baclofen [65] or tizanidine are sometimes used as an alternative to benzodiazepines. Tizanidine has been found to have superior tolerability compared to diazepam and baclofen. [66] Benzodiazepines are also used to treat the acute panic caused by hallucinogen intoxication. [67]
The first over-the-counter birth control pill will be available in U.S. stores later this month, allowing American women and teens to purchase contraceptive medication as easily as they buy aspirin.
The drug or other substance has a high potential for abuse. The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug or other substances may lead to severe psychological or physical dependence.
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