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Some drugs developed that include metals interact directly with other metals already present in protein active sites, while other drugs can use metals to interact with amino acids with the highest reduction potential. [4] Figure 2. Structure of Cisplatin, a platinum coordination complex. Examples of metals used in treatment include:
Carboplatin, an example of a metallopharmaceutical. A metallopharmaceutical is a drug that contains a metal as an active ingredient. [1] [2] Most commonly metallopharmaceuticals are used as anticancer or antimicrobial agents. The efficiency of metallopharmaceuticals is crucially dependent on the respective trace metal binding forms. [3]
Applications of iron oxide nanoparticles include terabit magnetic storage devices, catalysis, sensors, superparamagnetic relaxometry, high-sensitivity biomolecular magnetic resonance imaging, magnetic particle imaging, magnetic fluid hyperthermia, separation of biomolecules, and targeted drug and gene delivery for medical diagnosis and ...
Bioinorganic chemistry is a field that examines the role of metals in biology.Bioinorganic chemistry includes the study of both natural phenomena such as the behavior of metalloproteins as well as artificially introduced metals, including those that are non-essential, in medicine and toxicology.
In biology and medicine, nitric oxide is however an important signalling molecule in nature and this fact is the basis of the most important applications of metal nitrosyls. The nitroprusside anion, [Fe(CN) 5 NO] 2− , a mixed nitrosyl cyano complex, has pharmaceutical applications as a slow release agent for NO.
The use of gold compounds has decreased since the 1980s because of numerous side effects and monitoring requirements, limited efficacy, and very slow onset of action. Most chemical compounds of gold, including some of the drugs discussed below, are not salts, but are examples of metal thiolate complexes.
Carbon monoxide is one of three gaseous signaling molecules alongside nitric oxide and hydrogen sulfide. These gases are collectively referred to as gasotransmitters. CO is a classical example of hormesis such that low-dose is essential and beneficial, whereas an absence or excessive exposure to CO can be toxic.
Pages in category "Metal-containing drugs" The following 8 pages are in this category, out of 8 total. This list may not reflect recent changes. A. Auranofin;