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Diabetes mellitus is a disease in which the beta cells of the endocrine pancreas either stop producing insulin or can no longer produce it in enough quantity for the body's needs. The disease can affect humans as well as animals such as dogs. The condition is treatable and need not shorten the animal's life span or interfere with the quality of ...
Toxic in humans, dogs, and cats alike. Extremely dangerous to dogs (and children) due to its sweet taste. The antifreeze itself is not toxic, but is metabolized via the liver to the toxins glycolate and oxalate, which cause intoxication and vomiting, metabolic acidosis, and finally acute kidney failure leading to seizures and death. By the time ...
Maropitant (INN; [3] brand name: Cerenia, used as maropitant citrate , is a neurokinin-1 (NK 1) receptor antagonist developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007, for use in dogs [4] [5] and in 2012, for cats. [6]
Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
Some researchers are investigating how metformin, a common drug used to treat diabetes, may help prolong healthspan and lifespan. What evidence is there to support this notion?
A 2020 meta-analysis of 21 trials found that metformin treatment could reduce BMI by one unit. Beyond weight loss, there are more metformin benefits, including anti-tumor effects, and reducing the ...
The US Food and Drug Administration (FDA) recommends avoiding the use of metformin in more severe chronic kidney disease, below the eGFR cutoff of 30 mL/minute/1.73 m 2. [94] Lactate uptake by the liver is diminished with metformin use because lactate is a substrate for hepatic gluconeogenesis, a process that metformin inhibits.
2. Alleviates Hunger. Metformin improves how well your cells respond to insulin. This helps regulate your blood sugar levels and manage spikes in insulin that can trigger hunger and food cravings.
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