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Total iron-binding capacity (TIBC) or sometimes transferrin iron-binding capacity is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. [1] Transferrin can bind two atoms of ferric iron (Fe 3+ ) with high affinity.
Transferrin and TIBC Transferrin saturation Ferritin Transferrin receptor Related tests Hb MCV Iron deficiency anemia: Iron overload (hemochromatosis) * Normal Anemia of chronic disease * * Porphyria cutanea tarda (PCT) Normal Thalassemia Sideroblastic anemia * Megaloblastic anemia: Hemolytic anemia * * * * Pregnancy or use of
Transferrin saturation (TS), measured as a percentage, is a medical laboratory value. It is the value of serum iron divided by the total iron-binding capacity [1] of the available transferrin, the main protein that binds iron in the blood, this value tells a clinician how much serum iron is bound.
Ferritin genes are highly conserved between species. All vertebrate ferritin genes have three introns and four exons. [8] In human ferritin, introns are present between amino acid residues 14 and 15, 34 and 35, and 82 and 83; in addition, there are one to two hundred untranslated bases at either end of the combined exons. [9]
Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin and freely circulate in the blood. Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin molecules in red blood cells.
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The 'T' in TIBC does stand for 'total' after all, and it measures the ammount of iron that can be carried by transferrin the sample, period. Weather it is iron that the patient absorbed after breakfast or iron that the technician sprinkled on in the lab in order to make the determination makes no difference.