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Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
The drug is taken by mouth. [1] Side effects of armodafinil include headache, nausea, dizziness, and insomnia. [1] Armodafinil acts as a selective atypical dopamine reuptake inhibitor (DRI) and hence as an indirect dopamine receptor agonist. [1] [5] [11] However, other mechanisms might also be involved in its effects.
Of the more than twenty compounds preclinically tested in Cephalon's three-part drug discovery series, the compound fluorenol was selected as a lead. [26] Fluorenol was found to induce wakefulness to a greater degree than modafinil, despite possessing a lower affinity for the dopamine transporter (DAT). [ 26 ]
From 2017 to 2019, the unit spent about $46,500 on Ambien, a sleeping medication, which the report says is “174 times more expensive than the generic equivalent.”
According to Dr. Niteesh K. Choudhry, professor of medicine at Harvard Medical School and executive director of the Center for Healthcare Delivery Sciences at Brigham and Women’s Hospital, if ...
Drug name Withdrawn Country Remarks Amphetamine Mix (Adderall XR) 2005 Canada Withdrawn over reports of increased risk of stroke, reinstated after increased risk not found. [1] Alatrofloxacin: 2006 Worldwide Serious hepatotoxicity leading to liver transplant or death. [2] Alclofenac: 1979 UK Vasculitis [3] Alpidem (Ananxyl) 1995 Worldwide
The Best ED Medication for Men: Pros & Cons of Top ED Pills. Over the last 25 years, (ED) medications like Viagra and Cialis have become common fixtures in bedrooms around the world.
These are structural analogues and derivatives of modafinil, a drug that affects dopamine levels in the brain in an unusual way (atypical dopamine reuptake inhibitor or DRI). Modafinil is a drug that helps keep people awake and alert (wakefulness-promoting agent or "eugeroic"). [1] [2]
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