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Pupillary response is a physiological response that varies the size of the pupil between 1.5 mm and 8 mm, [1] via the optic and oculomotor cranial nerve. A constriction response , [2] is the narrowing of the pupil, which may be caused by scleral buckles or drugs such as opiates/opioids or anti-hypertension medications.
Convergence of the eyes, or the orientation of the visual axis of each eye towards an object in order to focus its image on each fovea, is the first of the three responses. This can be observed by the cross-eyed movement of the eyes when a finger is held up in front of a face and moved towards the face. Next, constriction of the pupil occurs.
The pupillary sphincter muscle and pupillary dilator muscle control the iris to adjust the size of the pupil to adjust how much light enters into the eye. The pupillary dilator muscle increases the pupillary diameter and it is arranged radially, but the pupillary sphincter muscle is responsible for the constriction of the pupil's diameter and ...
Nerves involved in the resizing of the pupil connect to the pretectal nucleus of the high midbrain, bypassing the lateral geniculate nucleus and the primary visual cortex. From the pretectal nucleus neurons send axons to neurons of the Edinger-Westphal nucleus whose visceromotor axons run along both the left and right oculomotor nerves .
Conversely, parasympathetic stimulation causes contraction of the circular muscle and constriction of the pupil. The mechanism of mydriasis depends on the agent being used. It usually involves either a disruption of the parasympathetic nerve supply to the eye (which normally constricts the pupil) or overactivity of the sympathetic nervous ...
It explains the defining features of a tonic pupil: (1) The pupil does not react to light. The original light-reaction neurons have been destroyed. (2) Tonic constriction with attempted near vision. Aberrant regeneration of nerve fibers intended for the ciliary muscle causes abnormal, tonic contraction of the pupil with accommodation.
The pupil constricts when the iris sphincter muscle is stimulated and contracts. In humans, it functions to constrict the pupil in bright light (pupillary light reflex) or during accommodation. [citation needed] In lower animals, the muscle cells themselves are photosensitive causing iris action without brain input. [5]
The oculomotor nerve also controls the constriction of the pupils and thickening of the lens of the eye. This can be tested in two main ways. By moving a finger toward a person's face to induce accommodation, their pupils should constrict. Shining a light into one eye should result in equal constriction of the other eye.