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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Set point theory can be construed as implying weight regulation in a wide or tight range around the set point, in a symmetric or in an asymmetric manner (i.e. treating weight gain and loss either the same or differently), and may apply to regulation of body fat levels specifically (in a multi-compartment model) or to overall body weight. Set ...
Gene–environment interaction (or genotype–environment interaction or G×E) is when two different genotypes respond to environmental variation in different ways. A norm of reaction is a graph that shows the relationship between genes and environmental factors when phenotypic differences are continuous. [ 1 ]
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On average obese people have a greater energy expenditure than normal weight or thin people and actually have higher basal metabolic rates. [45] [46] This is because it takes more energy to maintain an increased body mass. [47] Obese people also underreport how much food they consume compared to those of normal weight. [48]
Gene–environment correlations (or rGE) is correlation of two traits, e.g. height and weight, which would mean that when one changes, so does the other. Gene–environment correlations can arise by both causal and non-causal mechanisms. [1] Of principal interest are those causal mechanisms which indicate genetic control over environmental ...
Many of us believe we are masters of own destiny, but new research is revealing the extent to which our behavior is influenced by our genes. It’s now possible to decipher our individual genetic ...
According to the "thrifty gene hypothesis, [18] a genetic theory explaining rising obesity rates, certain individuals are genetically predisposed to metabolize food more efficiently than others as a result of human evolution. In times of scarcity, these genes were essential in ensuring survival; in times of abundance, these same genes cause ...