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With immunohistochemistry, the chief cells located in the cell balls are positive for chromogranin, synaptophysin, neuron specific enolase, serotonin, neurofilament and Neural cell adhesion molecule; they are S-100 protein negative. The sustentacular cells are S-100 positive and focally positive for glial fibrillary acidic protein.
Micrograph highlighting the sustentacular cells in a paraganglioma. S100 immunostain. A sustentacular cell is a type of cell primarily associated with structural support, they can be found in various tissues.
The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation. At least 21 different S100 proteins are known. [1] They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3.
Glomus tumors are usually solitary and small lesions. The vast majority are found in the hand, wrist, foot, and under the fingernails. [3]They are often painful, and the pain is reproduced when the lesion is placed in cold water - a history of sensitivity to cold weather is also common. [6]
Macy's has named 66 of the 150 stores that it's planning to close as part of its revitalization plan.. The retailer announced back in February 2024 plans to shut down 150 "underproductive" Macy's ...
Two people were found dead inside the landing gear of a JetBlue plane that flew out of New York City on Monday night. NBC6
The warning signs and safety concerns were obvious – to New Orleans residents, tourists and experts alike. Throngs of New Year’s Day revelers packed in the city’s bustling French Quarter had ...
A gangliocytic paraganglioma is a rare tumour that is typically found in the duodenum and consists of three components: (1) ganglion cells, (2) epithelioid cells (paraganglioma-like) and, (3) spindle cells (schwannoma-like).