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Glutethimide is a hypnotic sedative that was introduced by Ciba [3] in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similar withdrawal symptoms.
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Rogletimide, also known as pyridoglutethimide, is a medication which was never marketed. [1] It is related in chemical structure to the sedative/hypnotic drug glutethimide, but instead has pharmacological activity as a selective aromatase inhibitor similar to the related drug aminoglutethimide and has no significant sedative-hypnotic effect. [2]
The drug or other substance has a high potential for abuse. The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse of the drug or other substances may lead to severe psychological or physical dependence.
This word ending—thought to be difficult for Spanish speakers to pronounce at the time—evolved in Spanish into a "-te" ending (e.g. axolotl = ajolote). As a rule of thumb, a Spanish word for an animal, plant, food or home appliance widely used in Mexico and ending in "-te" is highly likely to have a Nahuatl origin.
Pyrithyldione [1] (Presidon, Persedon) is a psychoactive drug invented in 1949. [2] An improved method of manufacture was patented by Roche in 1959. [3] It was used as a hypnotic or sedative and presumed to be less toxic than barbiturates. [4]
Isovaleramide is a constituent of valerian root.. In humans, it acts as a mild anxiolytic at lower doses and as a mild sedative at higher dosages. [1] Isovaleramide has been shown to be non-cytotoxic and does not act as a CNS stimulant.
Aminoglutethimide (AG), sold under the brand names Elipten, Cytadren, and Orimeten among others, is a medication which has been used in the treatment of seizures, Cushing's syndrome, breast cancer, and prostate cancer, among other indications.