Search results
Results from the WOW.Com Content Network
Recent evidence indicates that the members of the LDL receptor gene family are active in the cell signalling pathways between specialized cells in many, if not all, multicellular organisms. [5] [6] There are seven members of the LDLR family in mammals, namely: LDLR; VLDL receptor ; ApoER2, or LRP8; Low density lipoprotein receptor-related protein 4
The receptor also recognizes apolipoprotein E (ApoE) which is found in chylomicron remnants and IDL. In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. [6] [7] [8] It belongs to the low density lipoprotein receptor gene family. [9] It is most significantly expressed in bronchial epithelial cells and adrenal gland ...
VLDLR is a member of the low-density-lipoprotein (LDL) receptor family, which is entirely composed of type I transmembrane lipoprotein receptors. The structural differences of the LDL receptor family. This image represents the similarities in structural domains among the members, as well as the extra cysteine repeat present on the VLDL receptor.
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the LRP1 protein is encoded by the ...
LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP5. In each protein, about 85% of its 1600-amino-acid length is extracellular. Each has four YWTD β-propeller motifs at the amino terminal end that alternate with four epidermal growth factor (EGF)-like repeats, followed by three LDLR type A repeats ...
Low-density lipoprotein, known as LDL, is a complex structure with several components that allow cholesterol to circulate in the bloodstream, a watery environment.
The role that is most commonly associated with this evolutionarily ancient gene family is the endocytosis and removal of low-density lipoprotein(LDL), the main carrier of cholesterol in the circulation of humans, by the liver. Indeed, the regulation of cholesterol homeostasis through this mechanism remains the sole known function of the family ...
In the central nervous system, Apo-E is mainly produced by astrocytes and transports cholesterol to neurons [8] via Apo-E receptors, which are members of the low density lipoprotein receptor gene family. [9] Apo-E is the principal cholesterol carrier in the brain. [10]