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Anti-Di b was found in 1967, establishing the Diego group as a two-antigen system. In 1993 the Diego pair of antigens was found to result from a single point mutation (nucleotide 2561) on what is now called the SLC4A1 gene on chromosome 17. [1] The Wright a antigen (Wr a), a very low frequency blood type, was also discovered in 1953.
Suppression of receptor-binding domain of LRP LDLR is due to overexpression of LRPAP (the protein product of LRPAP gene). [13] LRP gives protection across LDL by LRPAP and its downregulation may be subjected for an elevation of LDL and Ab-related neuronal toxicity as LRP supports in binding of ligand and internalization of LRP ligands like apo ...
16973 Ensembl ENSG00000162337 ENSMUSG00000024913 UniProt O75197 Q91VN0 RefSeq (mRNA) NM_001291902 NM_002335 NM_008513 RefSeq (protein) NP_001278831 NP_002326 NP_032539 Location (UCSC) Chr 11: 68.31 – 68.45 Mb Chr 19: 3.63 – 3.74 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 ...
It is caused by the presence of antibodies against anionic phospholipids and β2-glycoprotein I (β2GPI). The anti-β2GPI antibodies are most prevalent in causing the symptoms of the disease. When bound by an antibody, β2GPI begins to interact with monocytes, endothelial cells, and platelets. ApoER2 is thought to play a key role in the process ...
The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) [5] that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL).
[8] [10] [11] As a member of the LDLR family, LRP1 contains cysteine-rich complement-type repeats, EGF (gene) repeats, β-propeller domains, a transmembrane domain, and a cytoplasmic domain. [9] The extracellular domain of LRP1 is the alpha-chain, which comprises four ligand -binding domains (numbered I-IV) containing two, eight, ten, and ...
228357 Ensembl ENSG00000134569 ENSMUSG00000027253 UniProt O75096 Q8VI56 RefSeq (mRNA) NM_002334 NM_001145857 NM_172668 RefSeq (protein) NP_002325 NP_001139329 NP_766256 Location (UCSC) Chr 11: 46.86 – 46.92 Mb Chr 2: 91.29 – 91.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Low-density lipoprotein receptor-related protein 4 (LRP-4), also known as multiple epidermal growth ...
It is a human monoclonal antibody that belongs to a novel class of anti-cholesterol drugs, known as PCSK9 inhibitors, and it was the first such agent to receive FDA approval. The FDA approval was contingent on the completion of further clinical trials to better determine efficacy and safety.
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