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  2. Prion - Wikipedia

    en.wikipedia.org/wiki/Prion

    A prion / ˈ p r iː ɒ n / ⓘ is a misfolded protein that induces misfolding in normal variants of the same protein, leading to cellular death.Prions are responsible for prion diseases, known as transmissible spongiform encephalopathy (TSEs), which are fatal and transmissible neurodegenerative diseases affecting both humans and animals.

  3. Major prion protein - Wikipedia

    en.wikipedia.org/wiki/Major_prion_protein

    Others insert additional amino acids into the protein or cause an abnormally short protein to be made. These mutations cause the cell to make prion proteins with an abnormal structure. The abnormal protein PrP Sc accumulates in the brain and destroys nerve cells, which leads to the mental and behavioral features of prion diseases. [citation needed]

  4. Bovine spongiform encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Bovine_spongiform...

    BSE prions are misfolded forms of the particular brain protein called prion protein. When this protein is misfolded, the normal alpha-helical structure is converted into a beta sheet. The prion induces normally-folded proteins to take on the misfolded phenotype in an exponential cascade.

  5. Fungal prion - Wikipedia

    en.wikipedia.org/wiki/Fungal_prion

    Fungal prions are naturally occurring proteins that can switch between multiple, structurally distinct conformations, at least one of which is self-propagating and transmissible to other prions. This transmission of protein state represents an epigenetic phenomenon where information is encoded in the protein structure itself, instead of in ...

  6. Transmissible spongiform encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Transmissible_spongiform...

    The protein may also be involved in protecting brain cells and helping them communicate. [21] [22] Point mutations in this gene cause cells to produce an abnormal form of the prion protein, known as PrP Sc. This abnormal protein builds up in the brain and destroys nerve cells, resulting in the signs and symptoms of prion disease.

  7. PRND - Wikipedia

    en.wikipedia.org/wiki/PRND

    This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to ...

  8. Category:Prions - Wikipedia

    en.wikipedia.org/wiki/Category:Prions

    Pages in category "Prions" The following 14 pages are in this category, out of 14 total. ... Protein misfolding cyclic amplification; Stanley B. Prusiner; R.

  9. Structural inheritance - Wikipedia

    en.wikipedia.org/wiki/Structural_inheritance

    Prions based on heritable protein structure also exist in yeast. [2] [3] [4] Structural inheritance has also been seen in the orientation of cilia in protozoans such as Paramecium [5] and Tetrahymena, [6] and 'handedness' of the spiral of the cell in Tetrahymena, [6] and shells of snails.

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