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Tenofovir disoproxil is a pro-drug form of tenofovir phosphonate, which is liberated intracellularly and converted to tenofovir disphophate. [32] It is marketed by Gilead Sciences (as the fumarate, abbreviated TDF). [33] Tenofovir disoproxil is also available in pills which combine a number of antiviral drugs into a single dose.
It is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats.
Giving a cat a pill easily is not as big an issue as it once was since so many alternatives are now available, but a 2017 survey showed that about a fourth of medications sent home for cats are ...
List of Antiviral Drugs Antiviral Use Manufacturer Component Type Year approved Abacavir: HIV: ViiV Healthcare: Nucleoside analogue reverse transcriptase inhibitor (NRTI) 1998 Acyclovir (Aciclovir) Herpes Simplex, chickenpox, [2] varicella zoster virus: GSK: guanosine analogue RTI 1981 Adefovir: Hepatitis B [3] Gilead Sciences RTI 2002 , 2003 ...
Emtricitabine/tenofovir is also used for HIV post-exposure prophylaxis. People who start taking emtricitabine/tenofovir see HIV reduction benefits up to 72 hours after starting, but the medicine must be taken for thirty days after a high-risk sexual event to ensure HIV transmission levels are optimally reduced. [21] [22]
Chewable products that protect dogs and cats against fleas can cause neurological problems such as stumbling or seizures, and pet owners need more warning, the Food and Drug Administration said ...
The trial, CAPRISA 004, was conducted among 889 women to evaluate the ability of 1% tenofovir gel to prevent male-to-female HIV transmission. The study found a 39% lower HIV infection rate in women using 1% tenofovir gel compared with women using a placebo gel. In addition, tenofovir gel was shown to be safe as tested. [21]
An FDA advisory committee meets Tuesday to review Merck's Covid oral antiviral pill, molnupiravir, which can lower a person's risk of hospitalization.