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Gp41 also known as glycoprotein 41 is a subunit of the envelope protein complex of retroviruses, including human immunodeficiency virus (HIV). Gp41 is a transmembrane protein that contains several sites within its ectodomain that are required for infection of host cells.
The host-pathogen interaction is defined as how microbes or viruses sustain themselves within host organisms on a molecular, cellular, organismal or population level. This term is most commonly used to refer to disease-causing microorganisms although they may not cause illness in all hosts. [ 1 ]
HIV can infect a variety of immune cells such as CD4 + T cells, macrophages, and microglial cells. HIV-1 entry to macrophages and CD4 + T cells is mediated through interaction of the virion envelope glycoproteins (gp120) with the CD4 molecule on the target cells' membrane and also with chemokine co-receptors. [26] [44]
These cells express a CD4 receptor, to which HIV can bind, through the gp120 and gp41 proteins on its surface. [10] HIV also requires a second co-receptor along with the CD4-gp120 complex to enter the target cells - either CCR5 or CXCR4. [10] This demonstrates an example of how cell surface receptors can affect the tropism of a viral pathogen.
First is the 3’ processing of the HIV DNA, followed by strand transfer of the HIV DNA into the host DNA. The integration of HIV DNA can occur either in dividing or resting cells, and the HIV integrase enzyme can exist in the form of a monomer, dimer, tetramer, and possibly even higher-order forms (such as octomers). Each HIV particle has an ...
HIV can survive at room temperature outside the body for hours if dry (provided that initial concentrations are high), [31] and for weeks if wet (in used syringes/needles). [32] However, the amounts typically present in bodily fluids do not survive nearly as long outside the body—generally no more than a few minutes if dry. [23]
APOBEC3G is thus a host defence to retroviral infection which HIV-1 has overcome by the acquisition of Vif. [5] Vif 1 is additionally able to inhibit human A3C, A3D, A3F, and A3H haplotype II, [6] all of which can similarly be packaged and cause hypermutation in Vif-deficient HIV-1. Different surfaces on Vif 1 are used to bind A3C, A3F, and A3G ...
An infectious disease agent can be transmitted in two ways: as horizontal disease agent transmission from one individual to another in the same generation (peers in the same age group) [3] by either direct contact (licking, touching, biting), or indirect contact through air – cough or sneeze (vectors or fomites that allow the transmission of the agent causing the disease without physical ...