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Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
However, the modalities can be combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy. Another form of targeted therapy involves the use of nanoengineered enzymes to bind to a tumor cell such that the body's natural cell degradation process can digest the cell, effectively eliminating it from the ...
Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim only to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology. [1] [2]
Docetaxel is a cytotoxic chemotherapeutic agent. [12] [25] As with all chemotherapy, adverse effects are common, and many side effects have been documented. [17] [19] Because docetaxel is a cell-cycle-specific agent, it is cytotoxic to all dividing cells in the body. [26]
Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
After being diagnosed with stage 2 breast cancer earlier this year, TODAY contributor Jill Martin Brooks is getting honest and real about her chemotherapy journey.. She joined TODAY on Oct. 4 ...
Treating cells with the cytotoxic compound can result in a variety of prognoses. The cells may undergo necrosis , in which they lose membrane integrity and die rapidly as a result of cell lysis . The cells can stop actively growing and dividing (a decrease in cell viability), or the cells can activate a genetic program of controlled cell death ...
Chemotherapy-induced hyperpigmentation is caused by many chemotherapeutic agents (especially the antibiotics bleomycin, and daunorubicin) and the alkylating agents (cyclophosphamide and busulfan). [ 1 ] : 132