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Methotrexate, formerly known as amethopterin, is a chemotherapy agent and immune-system suppressant. [4] It is used to treat cancer , autoimmune diseases , and ectopic pregnancies . [ 4 ] Types of cancers it is used for include breast cancer , leukemia , lung cancer , lymphoma , gestational trophoblastic disease , and osteosarcoma . [ 4 ]
Therapeutic drug monitoring (TDM) is a branch of clinical chemistry and clinical pharmacology that specializes in the measurement of medication levels in blood. Its main focus is on drugs with a narrow therapeutic range , i.e. drugs that can easily be under- or overdosed. [ 1 ]
The antifolate drug methotrexate is often used to treat cancer because it inhibits the production of the active tetrahydrofolate (THF) from the inactive dihydrofolate (DHF). [55] However, methotrexate can be toxic, [56] [57] [58] producing side effects such as inflammation in the digestive tract that make eating normally more difficult. Bone ...
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A medical monitor or physiological monitor is a medical device used for monitoring. It can consist of one or more sensors , processing components, display devices (which are sometimes in themselves called "monitors"), as well as communication links for displaying or recording the results elsewhere through a monitoring network.
Clinical monitoring is the oversight and administrative efforts that monitor a participant's health and efficacy of the treatment during a clinical trial.Both independent and government-run grant-funding agencies, such as the National Institutes of Health (NIH) [1] and the World Health Organization (WHO), [2] require data and safety monitoring protocols for Phase I and II clinical trials ...
Caitlin Clark's brother, Colin, appeared to respond to Washington Mystics owner Sheila Johnson's recent comments about his sister's Time magazine cover for Athlete of the Year.
[54] [115] Long-term treatment with methotrexate is associated with liver damage in about 10% of people and hence may be a significant concern in people with liver involvement and requires regular liver function test monitoring. [19] Methotrexate can also lead to pulmonary toxicity (lung damage), although this is fairly uncommon and more ...