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Hypercapnia (from the Greek hyper, "above" or "too much" and kapnos, "smoke"), also known as hypercarbia and CO 2 retention, is a condition of abnormally elevated carbon dioxide (CO 2) levels in the blood. Carbon dioxide is a gaseous product of the body's metabolism and is normally expelled through the lungs.
Monitoring the level of carbon dioxide in neonatal infants to ensure that the level is not too high (hypercarbia) or too low is important for improving outcomes for neonates in intensive care. [4] Carbon dioxide can be monitored by taking a blood sample ( arterial blood gas ), through the breath ( exhalation ), and it can be measured ...
Hypercarbia (too much carbon dioxide in the blood) may contribute to the development of bronchopulmonary dysplasia. [22] Monitoring the level of carbon dioxide in neonatal infants to ensure that the level is not too high or too low ( hypocarbia ) is important for improving outcomes for neonates in intensive care. [ 23 ]
Respiratory failure is classified as either Type 1 or Type 2, based on whether there is a high carbon dioxide level, and can be acute or chronic. In clinical trials, the definition of respiratory failure usually includes increased respiratory rate , abnormal blood gases (hypoxemia, hypercapnia, or both), and evidence of increased work of breathing.
Blood oxygen levels fall and carbon dioxide rises, resulting in rising blood acid levels and hypoxia. Structural immaturity, as manifested by a decreased number of gas exchange units and thicker walls, also contributes to the disease process. Therapeutic oxygen and positive-pressure ventilation, while potentially life-saving, can damage the lung.
Acute respiratory acidosis occurs when an abrupt failure of ventilation occurs. This failure in ventilation may be caused by depression of the central respiratory center by cerebral disease or drugs, inability to ventilate adequately due to neuromuscular disease (e.g., myasthenia gravis, amyotrophic lateral sclerosis, Guillain–Barré syndrome, muscular dystrophy), or airway obstruction ...
An arterial blood gas (ABG) test, or arterial blood gas analysis (ABGA) measures the amounts of arterial gases, such as oxygen and carbon dioxide.An ABG test requires that a small volume of blood be drawn from the radial artery with a syringe and a thin needle, [1] but sometimes the femoral artery in the groin or another site is used.
When the baby is born, the lungs are needed for oxygen transfer and need high blood flow which is encouraged by low PVR. The failure of the circulatory system of the newborn to adapt to these changes by lowering PVR leads to persistent fetal circulation. [2] The newborn is therefore born with elevated PVR, which leads to pulmonary hypertension.