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In mammals, the first part of oogenesis starts in the germinal epithelium, which gives rise to the development of ovarian follicles, the functional unit of the ovary. Oogenesis consists of several sub-processes: oocytogenesis, ootidogenesis, and finally maturation to form an ovum (oogenesis proper).
Diagram showing the reduction in number of the chromosomes in the process of maturation of the ovum; the process is known as meiosis Main article: Oogenesis The formation of an oocyte is called oocytogenesis, which is a part of oogenesis. [ 1 ]
An ovarian follicle is a roughly spheroid cellular aggregation set found in the ovaries. It secretes hormones that influence stages of the menstrual cycle . In humans, women have approximately 200,000 to 300,000 follicles at the time of puberty , [ 1 ] [ 2 ] each with the potential to release an egg cell (ovum) at ovulation for fertilization ...
A diagram of the ovary of the fruit fly Drosophila melanogaster, showing multiple ovarioles within the two ovaries, each containing multiple developing oocytes.. In the fruit fly Drosophila melanogaster, a common model organism for developmental research, each ovary typically contains between 16 and 20 polytrophic meroistic ovarioles. [4]
Development proceeds and the oogonia become fully surrounded by a layer of connective tissue cells (pre-granulosa cells) in an irregular manner. In this way, the rudiments of the ovarian follicles are formed. During oogenesis, the oogonia become primary oocytes.
The process of ovulation and gamete production, oogenesis, in a human ovary. The ovaries are the site of production and periodical release of egg cells, the female gametes. In the ovaries, the developing egg cells (or oocytes) mature in the fluid-filled follicles. Typically, only one oocyte develops at a time, but others can also mature ...
CCs primarily support growth and development of the oocyte whereas MGCs primarily serve an endocrine function and support the growth of the follicle. Cumulus cells aid in oocyte development and show higher expression of SLC38A3, a transporter for amino acids, and Aldoa, Eno1, Ldh1, Pfkp, Pkm2, and Tpi1, enzymes responsible for glycolysis. [ 7 ]
Folliculogenesis is continuous, meaning that at any time the ovary contains follicles in many stages of development. The majority of follicles die and never complete development. A few develop fully to produce a secondary oocyte which is released by rupture of the follicle in a process called ovulation .