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Before 24 February 2020, over 95% of all deaths from COVID-19 worldwide had occurred in Hubei province, where Wuhan is located. [183] [184] As of 10 March 2023, the percentage had decreased to 0.047%. [180] As of 10 March 2023, there were 676,609,955 total confirmed cases of SARS‑CoV‑2 infection. [180]
SARS-CoV-2 is the virus that causes coronavirus disease 2019 (COVID-19). Some have been stated, to be of particular importance due to their potential for increased transmissibility, [1] increased virulence, or reduced effectiveness of vaccines against them. [2] [3] These variants contribute to the continuation of the COVID-19 pandemic.
Coronavirus diseases are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in mammals and birds. In humans and birds, the group of viruses cause respiratory tract infections that can range from mild to lethal.
On July 7, a preprint study from epidemiologists at the University of Toronto found that Delta had a 120% greater – or more than twice as large – risk of hospitalization, 287% greater risk of ICU admission and 137% greater risk of death compared to non-variant of concern strains of SARS-COV-2. [131]
Eradication is widely believed to be impossible, especially in the absence of a vaccine that provides long-lasting immunity against infection from COVID-19. [1] While all of the other outcomes are possible – sporadic, epidemic, pandemic, or endemic – many experts believe that COVID-19 is most likely to become endemic.
The CDC estimates that, between February 2020 and September 2021, only 1 in 1.3 COVID-19 deaths were attributed to COVID-19. [2] The true COVID-19 death toll in the United States would therefore be higher than official reports, as modeled by a paper published in The Lancet Regional Health – Americas . [ 3 ]
U.S. COVID infections are hovering near levels of the pandemic’s first peak in 2020, and approaching the Delta peak of late 2021, according to wastewater surveillance and modeling by forecasters.
A nationwide survey of randomly selected positive COVID-19 samples first analysed by a RT-PCR screening test and subsequently confirmed by genome sequencing, revealed that the variant grew from a share of 3.3% (388/11916) on 7–8 January (week 1) [123] to 13.3% (475/3561) on 27 January (week 4), [85] followed by 44.3% (273/615) on 16 February ...