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It is reported to have an elimination half-life of 2.8 hours, [3] although a review of 14 studies found that the mean terminal half-life ranged between 2 and 11 hours, and one study even reported a terminal half-life of 33 hours. [5] Buspirone is metabolized primarily by CYP3A4, and prominent drug interactions with inhibitors and inducers of ...
Syncope; Hypotension; Hypertension; Redness and itching of the eyes; Altered taste; Conjunctivitis; Flatulence; Anorexia; Increased appetite; Salivation; Rectal bleeding
Unlike benzodiazepines, azapirones lack abuse potential and are not addictive, do not cause cognitive/memory impairment or sedation, and do not appear to induce appreciable tolerance or physical dependence. However, azapirones are considered less effective with slow onset in controlling symptoms.
I have moderate GAD. I started taking Buspar 2.5 years ago. I am amazed at how well this drug works. It makes me dizzy about 30 minutes after I take it. The feeling lasts only for about an hour. I get very sleepy from the drug. I take my first dose early in the morning and fall back to sleep. I take my second dose before I fall asleep in the night.
Buspirone/testosterone (tentative brand name Lybridos) is a combination of buspirone, a 5-HT 1A receptor partial agonist, α 2-adrenergic receptor antagonist, and D 2 autoreceptor antagonist, [1] and testosterone, an androgen or androgen receptor agonist, which is under development by the pharmaceutical company Emotional Brain for the treatment of female sexual dysfunction.
All compounds submitted by the chemical staff for central nervous activity were screened. It was this battery of tests that picked out RO 5-0690 (Librium, chlordiazepoxide) as being similar but more potent than meprobamate." [34] Three years later chlordiazepoxide was marketed as a therapeutic benzodiazepine medication under the brand name Librium.
Gepirone is indicated for the treatment of major depressive disorder (MDD) in adults. [1] Of 15 clinical trials of gepirone for major depressive disorder submitted to the U.S. Food and Drug Administration (FDA), three were excluded for methodological reasons, three were deemed "failed" and "uninformative", seven were deemed negative and did not demonstrate effectiveness, and two were deemed ...
Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic) [10] medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and is sometimes used in low dosage to treat anxiety and mild depression.