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In the 1920s, Kyusaku Ogino, a Japanese gynecologist, and Hermann Knaus, from Austria, working independently, each made the discovery that ovulation occurs about fourteen days before the next menstrual period. [13] Ogino used his discovery to develop a formula for use in aiding infertile women to time intercourse to achieve pregnancy.
The latter undergo a period of proliferation and mucification known as cumulus expansion. Mucification is the secretion of a hyaluronic acid-rich cocktail that disperses and gathers the cumulus cell network in a sticky matrix around the ovum. This network stays with the ovum after ovulation and has been shown to be necessary for fertilization.
The time with the highest likelihood of pregnancy resulting from sexual intercourse covers the menstrual cycle time from some 5 days before until 1 to 2 days after ovulation. [10] In a 28‑day cycle with a 14‑day luteal phase, this corresponds to the second and the beginning of the third week.
[13] [14] The result is approximately 280 days (40 weeks) from the start of the last menstrual period. Another method is by adding 9 months and 7 days to the first day of the last menstrual period. Naegele's rule is named after Franz Karl Naegele, the German obstetrician who devised the rule. Naegele was born July 12, 1778, in Düsseldorf, Germany.
"Women in their mid- to late 40s who become pregnant are at higher risk for complications in pregnancy, such as hypertension, gestational diabetes, poor fetal growth and operative delivery," Dr ...
Young women may have felt a greater urgency to act than their male partners in the wake of policy changes because pregnancy disproportionately affects them, said Dr. Angela Liang, a clinical ...
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