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The immunological theory of aging suggests that the immune system weakens as an organism ages. This makes the organism unable to fight infections and less able to destroy old and neoplastic cells. This leads to aging and will eventually lead to death. This theory of aging was developed by Roy Walford in 1969.
The mitochondrial theory of ageing has two varieties: free radical and non-free radical. The first is one of the variants of the free radical theory of ageing. It was formulated by J. Miquel and colleagues in 1980 [1] and was developed in the works of Linnane and coworkers (1989). [2] The second was proposed by A. N. Lobachev in 1978. [3]
Immunosenescence is the gradual deterioration of the immune system, brought on by natural age advancement. A 2020 review concluded that the adaptive immune system is affected more than the innate immune system. [1] Immunosenescence involves both the host's capacity to respond to infections and the development of long-term immune memory.
Even more than strength or mobility, recent research says you need to look to your balance to determine longevity.
When your immune system tires out, disease risk goes up. But there are ways to keep your immunity young and strong. Chronic Stress May Speed Up Immune System Aging, Study Suggests
Stress may precipitate abuse of drugs and/or alcohol. [5] Stress may also contribute to aging and chronic diseases in aging, such as depression and metabolic disorders. [49] The immune system also plays a role in stress and the early stages of wound healing.
Telomere dysfunction during cellular aging (a state in which cells do not divide but are metabolically active) affects the health of the body. [2] Preventing telomere shortening without clearing old cells may lead to the accumulation of these cells in the body and contribute to age-related diseases and tissue dysfunction.
The metabolic stability theory of aging suggests it is the cells ability to maintain stable concentration of ROS which is the primary determinant of lifespan. [37] This theory criticizes the free radical theory because it ignores that ROS are specific signalling molecules which are necessary for maintaining normal cell functions. [37]