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Phosphoglycerate kinase (EC 2.7.2.3) (PGK 1) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP : 1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP. Like all kinases it is a transferase. PGK is a major enzyme used in ...
5230 18655 Ensembl ENSG00000102144 ENSMUSG00000062070 UniProt P00558 P09411 RefSeq (mRNA) NM_000291 NM_008828 RefSeq (protein) NP_000282 NP_032854 Location (UCSC) Chr X: 77.91 – 78.13 Mb Chr X: 105.23 – 105.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phosphoglycerate kinase 1 is an enzyme that in humans is encoded by the PGK1 gene. Interactive pathway map Click on genes ...
The first substrate-level phosphorylation occurs after the conversion of 3-phosphoglyceraldehyde and Pi and NAD+ to 1,3-bisphosphoglycerate via glyceraldehyde 3-phosphate dehydrogenase. 1,3-bisphosphoglycerate is then dephosphorylated via phosphoglycerate kinase, producing 3-phosphoglycerate and ATP through a substrate-level phosphorylation.
This step is the enzymatic transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP by phosphoglycerate kinase, forming ATP and 3-phosphoglycerate. At this step, glycolysis has reached the break-even point: 2 molecules of ATP were consumed, and 2 new molecules have now been synthesized.
1,3-Bisphosphoglyceric acid (1,3-Bisphosphoglycerate or 1,3BPG) is a 3-carbon organic molecule present in most, if not all, living organisms.It primarily exists as a metabolic intermediate in both glycolysis during respiration and the Calvin cycle during photosynthesis. 1,3BPG is a transitional stage between glycerate 3-phosphate and glyceraldehyde 3-phosphate during the fixation/reduction of ...
For example, phosphoglycerate kinase deficiency (gene PGK1) has a myopathic form. Also, Fanconi-Bickel syndrome (gene SLC2A2) and Danon disease (gene LAMP2) were declassed as GSDs due to being defects of transport proteins rather than enzymes ; however, GSD-1 subtypes b, c, and d are due to defects of transport proteins (genes SLC37A4, SLC17A3 ...
n/a Ensembl ENSG00000213290 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 19: 12.56 – 12.56 Mb n/a PubMed search n/a Wikidata View/Edit Human Phosphoglycerate kinase 1, pseudogene 2 is a protein that in humans is encoded by the PGK1P2 gene. References ^ a b c GRCh38: Ensembl release 89: ENSG00000213290 – Ensembl, May 2017 ^ "Human PubMed Reference ...
Phosphoglycerate kinase 1 is an enzyme involved in the conversion of 1,3-bisphosphoglycerate (1,3-BPG) to 3-phosphoglycerate (3-P-G) leading the production of ATP from ADP. Induction of gene expression by HIF-1 is thought to be dependent on the presence of aromatic hydrocarbon receptor nuclear translocator (ARNT1).