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Phosphoglycerate kinase (EC 2.7.2.3) (PGK 1) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP : 1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP. Like all kinases it is a transferase.
In enzymology, a phosphoglycerate kinase (GTP) (EC 2.7.2.10) is an enzyme that catalyzes the chemical reaction. GTP + 3-phospho-D-glycerate GDP + 3-phospho-D-glyceroyl phosphate. Thus, the two substrates of this enzyme are GTP and 3-phospho-D-glycerate, whereas its two products are GDP and 3-phospho-D-glyceroyl phosphate.
3-Phosphoglyceric acid (3PG, 3-PGA, or PGA) is the conjugate acid of 3-phosphoglycerate or glycerate 3-phosphate (GP or G3P). [1] This glycerate is a biochemically significant metabolic intermediate in both glycolysis and the Calvin-Benson cycle. The anion is often termed as PGA when referring to the Calvin-Benson cycle.
The first substrate-level phosphorylation occurs after the conversion of 3-phosphoglyceraldehyde and Pi and NAD+ to 1,3-bisphosphoglycerate via glyceraldehyde 3-phosphate dehydrogenase. 1,3-bisphosphoglycerate is then dephosphorylated via phosphoglycerate kinase, producing 3-phosphoglycerate and ATP through a substrate-level phosphorylation.
In enzymology, a 3-phosphoglyceroyl-phosphate—polyphosphate phosphotransferase (EC 2.7.4.17) is an enzyme that catalyzes the chemical reaction 3-phospho-D-glyceroyl phosphate + (phosphate)n ⇌ {\displaystyle \rightleftharpoons } 3-phosphoglycerate + (phosphate)n + 1
This step is the enzymatic transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP by phosphoglycerate kinase, forming ATP and 3-phosphoglycerate. At this step, glycolysis has reached the break-even point: 2 molecules of ATP were consumed, and 2 new molecules have now been synthesized.
5230 18655 Ensembl ENSG00000102144 ENSMUSG00000062070 UniProt P00558 P09411 RefSeq (mRNA) NM_000291 NM_008828 RefSeq (protein) NP_000282 NP_032854 Location (UCSC) Chr X: 77.91 – 78.13 Mb Chr X: 105.23 – 105.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phosphoglycerate kinase 1 is an enzyme that in humans is encoded by the PGK1 gene. Interactive pathway map Click on genes ...
1,3-Bisphosphoglyceric acid (1,3-Bisphosphoglycerate or 1,3BPG) is a 3-carbon organic molecule present in most, if not all, living organisms.It primarily exists as a metabolic intermediate in both glycolysis during respiration and the Calvin cycle during photosynthesis. 1,3BPG is a transitional stage between glycerate 3-phosphate and glyceraldehyde 3-phosphate during the fixation/reduction of ...