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Due to excitotoxicity, hypoxic death of cells within the central nervous system can result in liquefactive necrosis. [1] This is a process in which lysosomes turn tissues into pus as a result of lysosomal release of digestive enzymes. Loss of tissue architecture means that the tissue can be liquefied.
Caustic ingestion occurs when someone accidentally or deliberately ingests a caustic or corrosive substance.Depending on the nature of the substance, the duration of exposure and other factors it can lead to varying degrees of damage to the oral mucosa, the esophagus, and the lining of the stomach.
A 2016 analysis of emergency department visits from 2010 to 2013 reported over 36,000 visits annually for chemical burns to the eye, with a median age at presentation of 32 years. [4] By individual year of age, 1- and 2-year-old children have the highest incidence of these injuries, with rates approximately 50% higher than the highest-risk ...
First, methanol (whether it enters the body by ingestion, inhalation, or absorption through the skin) can be fatal due to its CNS depressant properties in the same manner as ethanol poisoning. Second, in a process of toxication , it is metabolized to formic acid (which is present as the formate ion) via formaldehyde in a process initiated by ...
It occurs when exposure to a substance – specifically, a neurotoxin or neurotoxicant– alters the normal activity of the nervous system in such a way as to cause permanent or reversible damage to nervous tissue. [1] This can eventually disrupt or even kill neurons, which are cells that transmit and process signals in the brain and other ...
Toxic encephalopathy is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations of any natural toxin such as cyanotoxins found in shellfish or freshwater ...
Exposure to lower concentrations can result in eye irritation, a sore throat and cough, nausea, shortness of breath, and fluid in the lungs. [59] These effects are believed to be due to hydrogen sulfide combining with alkali present in moist surface tissues to form sodium sulfide, a caustic. [66] These symptoms usually subside in a few weeks.
Chronic solvent-induced encephalopathy (CSE) is a condition induced by long-term exposure to organic solvents, often—but not always—in the workplace, that lead to a wide variety of persisting sensorimotor polyneuropathies and neurobehavioral deficits even after solvent exposure has been removed.