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Immune privilege is thought to be an evolutionary adaptation to protect vital structures from the potentially damaging effects of an inflammatory immune response. Inflammation in the brain or eye can lead to loss of organ function, while immune responses directed against a fetus can lead to miscarriage .
The placenta functions as an immunological barrier between the mother and the fetus, creating an immunologically privileged site. For this purpose, it uses several mechanisms: It secretes neurokinin B containing phosphocholine molecules. This is the same mechanism used by parasitic nematodes to avoid detection by the immune system of their host ...
HDFN represents a breach of immune privilege for the fetus or some other form of impairment of the immune tolerance in pregnancy. Various types of HDFN are classified by which alloantigen provokes the response. The types include ABO, anti-RhD, anti-RhE, anti-Rhc, anti-Rhe, anti-RhC, multiantigen combinations, and anti-Kell.
Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles. [12] [13] Risk factors include a family history of the condition. [7] Among identical twins, if one is affected, the other has about a 50% chance of also being affected. [7]
In an early-stage clinical trial led by the Dana-Farber Cancer Institute in Boston, a personalized vaccine prompted an anti-cancer immune response in all nine participants. These patients had been ...
The 15-second spot encourages women of all ages to understand their chances of developing breast cancer — the second most common cancer among women in the U.S., according to the Centers for ...
The Amateur Athletics Union even went as far as prohibiting women from running more than 1.5 miles (2.4 km) and the organizers of the Boston Marathon did not want to “take the liability” of ...
The presence of immune-privilege in the human testis is controversial and insufficient evidence exists to either confirm or rule out this phenomenon. Evidence for human/primate testicular immune privilege: Sperm are protected from autoimmune attack, which when it occurs in humans leads to infertility. [54]