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Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 27 ]
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
A computerised nursing care plan is a digital way of writing the care plan, compared to handwritten. Computerised nursing care plans are an essential element of the nursing process. [8] Computerised nursing care plans have increased documentation of signs and symptoms, associated factors and nursing interventions. [8]
The European Journal of Oncology Nursing is a peer-reviewed medical journal covering cancer research of direct relevance to patient care, nurse education, management, and policy development. It is published by Elsevier .
Emergency nursing is a specialty within the field of professional nursing focusing on the care of patients who require prompt medical attention to avoid long-term disability or death. In addition to addressing "true emergencies," emergency nurses increasingly care for people who are unwilling or unable to get primary medical care elsewhere and ...
International Emergency Nursing is a peer-reviewed nursing journal covering emergency healthcare. It is published quarterly by Elsevier and is an official publication of the European Society of Emergency Nurses and the Faculty of Emergency Nursing. [1] It was established in 1993 as Accident and Emergency Nursing [2] and obtained its current ...
In medicine, an indication is a valid reason to use a certain test, medication, procedure, or surgery. [1] There can be multiple indications to use a procedure or medication. [2]