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  2. GABA receptor agonist - Wikipedia

    en.wikipedia.org/wiki/GABA_receptor_agonist

    Gamma-aminobutyric acid, a GABA-B receptor agonist. A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1] There are three receptors of the gamma-aminobutyric acid. The ...

  3. Benzodiazepine - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine

    The GABA A receptor is a protein complex located in the synapses between neurons. All GABA A receptors contain an ion channel that conducts chloride ions across neuronal cell membranes and two binding sites for the neurotransmitter gamma-aminobutyric acid (GABA), while a subset of GABA A receptor complexes also contain a single binding site for ...

  4. Why Do Dogs Sleep So Much? Here's What the Experts Say - AOL

    www.aol.com/why-dogs-sleep-much-heres-113000342.html

    Dogs sleep for such a long time because that's when their body rests, resets, and heals, even if their awkward sleeping position implies otherwise. This is also when puppies do the most growing ...

  5. Effects of long-term benzodiazepine use - Wikipedia

    en.wikipedia.org/wiki/Effects_of_long-term...

    Although benzodiazepines can put people to sleep, while asleep, the drugs disrupt sleep architecture, decreasing sleep time, delayed and decreased REM sleep, increased alpha and beta activity, decreased K complexes and delta activity, and decreased deep slow-wave sleep (i.e., NREM stages 3 and 4, the most restorative part of sleep for both ...

  6. GABAA receptor positive allosteric modulator - Wikipedia

    en.wikipedia.org/wiki/GABAA_receptor_positive...

    In pharmacology, GABA A receptor positive allosteric modulators, also known as GABAkines or GABA A receptor potentiators, [1] are positive allosteric modulator (PAM) molecules that increase the activity of the GABA A receptor protein in the vertebrate central nervous system. GABA is a major inhibitory neurotransmitter in the central nervous system.

  7. Gabapentin - Wikipedia

    en.wikipedia.org/wiki/Gabapentin

    Specifically, it is a derivative of GABA with a pentyl disubstitution at 3 position, hence, the name - gabapentin, in such a way as to form a six-membered ring. After the formation of the ring, the amine and carboxylic groups are not in the same relative positions as they are in the GABA; [103] they are more conformationally constrained. [104]

  8. GABA reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/GABA_reuptake_inhibitor

    A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]

  9. Temazepam - Wikipedia

    en.wikipedia.org/wiki/Temazepam

    The guidelines found that temazepam at a dose of 15 mg reduces sleep latency by 37 minutes (95% CI Tooltip confidence interval 21 to 53 minutes), increases total sleep time by 99 minutes (95% CI 63 to 135 minutes), and provides a small improvement to sleep quality. [19]

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