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Atherogenicity of oxidized LDL has been explained by lack of recognition of oxidation-modified LDL structures by the LDL receptors, preventing the normal metabolism of LDL particles and leading eventually to development of atherosclerotic plaques. [23]
LDL circulates and is absorbed by the liver and peripheral cells. Binding of LDL to its target tissue occurs through an interaction between the LDL receptor and apolipoprotein B-100 on the LDL particle. Absorption occurs through endocytosis, and the internalized LDL particles are hydrolyzed within lysosomes, releasing lipids, chiefly cholesterol.
The results suggest that switching out meat for plant-based meat alternatives for eight weeks or less may help lower cholesterol by 6.6% and LDL cholesterol by 12.1%.
Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, Lp(a), IDL, and LDL particles (LDL—commonly known as "bad cholesterol" when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules , including cholesterol, around the body to all cells within all tissues. While ...
Soluble fiber helps reduce total and LDL cholesterol for better heart health while also promoting gut health and supporting weight management. To work more soluble fiber in your diet, focus on ...
LDL is often called “bad” cholesterol because high levels of it can lead to plaque buildup in your arteries, increasing the risk of heart disease and stroke, the CDC and Heart.org explain.
Hypercholesterolemia, also called high cholesterol, is the presence of high levels of cholesterol in the blood. [1] It is a form of hyperlipidemia (high levels of lipids in the blood), hyperlipoproteinemia (high levels of lipoproteins in the blood), and dyslipidemia (any abnormalities of lipid and lipoprotein levels in the blood).
Similarly better understanding risk factors for glaucoma may help us elucidate some of the more mysterious mechanisms of glaucoma, which can occur and progress seemingly independent of elevated ...
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