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Databases for oncogenomic research are biological databases dedicated to cancer data and oncogenomic research. They can be a primary source of cancer data, offer a certain level of analysis (processed data) or even offer online data mining .
The Reproducibility Project is a series of crowdsourced collaborations aiming to reproduce published scientific studies, finding high rates of results which could not be replicated. It has resulted in two major initiatives focusing on the fields of psychology [ 1 ] and cancer biology. [ 2 ]
In cancer cells, the RAS protein becomes persistently active, thus promoting the proliferation of the cell due to the absence of any regulation. [25] Additionally, most cancer cells carry two mutant copies of the regulator gene p53, which acts as a gatekeeper for damaged genes and initiates apoptosis in malignant cells.
The hallmarks of cancer were originally six biological capabilities acquired during the multistep development of human tumors and have since been increased to eight capabilities and two enabling capabilities. The idea was coined by Douglas Hanahan and Robert Weinberg in their paper "The Hallmarks of Cancer" published January 2000 in Cell. [1]
Welcome to WikiProject Biology, a WikiProject for discussing biology-related articles, editing issues, projects, and guidelines.The purpose of this project is to provide common ground for editors working in all biology-related projects, for seeking advice or requesting help from a broader community of biology editors, and for coordinating the categorization of biology articles.
Results from The Reproducibility Project: Cancer Biology suggest most studies of the cancer research sector may not be replicable. In a 2012 paper, C. Glenn Begley , a biotech consultant working at Amgen , and Lee Ellis, a medical researcher at the University of Texas, found that only 11% of 53 pre-clinical cancer studies had replications that ...
The Cancer Genome Atlas (TCGA) is a project to catalogue the genomic alterations responsible for cancer using genome sequencing and bioinformatics. [1] [2] The overarching goal was to apply high-throughput genome analysis techniques to improve the ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of the disease.
The Network of Cancer Genes (NCG) is a freely accessible web resource of genes that, when altered in their sequence, drive clonal expansion of normal tissues (healthy drivers) or cancer (cancer drivers). The project was launched in 2010 and has reached its 7th release in 2022.