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Dantrolene sodium, the only available medical treatment for malignant hyperthermia The current treatment of choice is the intravenous administration of dantrolene , the only known antidote, discontinuation of triggering agents, and supportive therapy directed at correcting hyperthermia, acidosis, and organ dysfunction.
The efficacy of dantrolene in humans was later confirmed in a large, multicenter study published in 1982, [21] and confirmed epidemiologically in 1993. [22] Before dantrolene, the only available treatment for malignant hyperthermia was procaine, which was associated with a 60% mortality rate in animal models. [20]
The hydantoin derivative dantrolene is used as a muscle relaxant to treat malignant hyperthermia, neuroleptic malignant syndrome, spasticity, and ecstasy intoxication. Ropitoin is an example of an antiarrhythmic hydantoin.
Dantrolene has been used when needed to reduce muscle rigidity, and dopamine pathway medications such as bromocriptine have shown benefit. [44] Dantrolene may act centrally on thermoregulatory pathways to lower the temperature. [7] Dantrolene also inhibits calcium release from the muscle sarcoplasmic reticulum to cause muscle relaxation. [7]
There is no simple, straightforward test to diagnose the condition. When MH develops during a procedure, treatment with dantrolene sodium is usually initiated; dantrolene and the avoidance of suxamethonium administration in susceptible people have markedly reduced the mortality from this condition.
The urgency and medical severity of the condition needs to be given impetus in terms of handling patients with Bell's Mania. Due to the homologous nature of this syndrome with malignant hyperthermia (MH) and neuroleptic malignant syndrome (NMS), [31] Dantrolene [32] is also a probable treatment route owing to its swift acidosis correction ...
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Azumolene is an experimental drug which is a derivative of dantrolene. In animal studies, azumolene showed similar efficacy to dantrolene at controlling symptoms of malignant hyperthermia but with better water solubility and lower toxicity, albeit with lower potency. [1] [2] [3]