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Whooping cough (/ ˈ h uː p ɪ ŋ / or / ˈ w uː p ɪ ŋ /), also known as pertussis or the 100-day cough, is a highly contagious, vaccine-preventable bacterial disease. [1] [10] Initial symptoms are usually similar to those of the common cold with a runny nose, fever, and mild cough, but these are followed by two or three months of severe coughing fits. [1]
What is happening with the whooping cough outbreak? Data from the CDC show that whooping cough cases have skyrocketed this year. In 2024, there have been 16,375 recorded cases of pertussis ...
Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus bacterium of the genus Bordetella, and the causative agent of pertussis or whooping cough. Its virulence factors include pertussis toxin , adenylate cyclase toxin , filamentous haemagglutinin , pertactin , fimbria , and tracheal cytotoxin .
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Respiratory sounds, also known as lung sounds or breath sounds, are the specific sounds generated by the movement of air through the respiratory system. [1] These may be easily audible or identified through auscultation of the respiratory system through the lung fields with a stethoscope as well as from the spectral characteristics of lung sounds. [2]
Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by Bordetella pertussis, [1] Vibrio fischeri (as a symbiosis chemical), [2] and Neisseria gonorrhoeae (among other peptidoglycan-derived cytotoxins it produces). [3]
This typically clears particles from the bronchi and trachea, the tubes that feed air to lung tissue from the nose and mouth. [1] The larynx (voice box) and carina (at the bottom of the trachea, as it splits into bronchi) are especially sensitive. Cough receptors in the surface cells of the respiratory tract are also sensitive to chemicals
Pertussis vaccine is a vaccine that protects against whooping cough (pertussis). [ 1 ] [ 2 ] There are two main types: whole-cell vaccines and acellular vaccines. [ 1 ] [ 2 ] The whole-cell vaccine is about 78% effective while the acellular vaccine is 71–85% effective.