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This illustration demonstrates the normal kidney physiology, including the Proximal Convoluted Tubule (PCT), Loop of Henle, and Distal Convoluted Tubule (DCT). It also includes illustrations showing where some types of diuretics act, and what they do. Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney.
Unlike mammals, the kidneys of reptiles do not have a clear distinction between cortex and medulla. [43] The kidneys lack the loop of Henle, have fewer nephrons (from about 3,000 to 30,000), and cannot produce hypertonic urine. [3] [21] Nitrogenous waste products excreted by the kidneys may include uric acid, urea and ammonia. [55]
The kidneys are susceptible to toxic injury, since toxins are reabsorbed in the tubules along with most of the filtered substances. [47] The kidneys are able to restore their functionality after acute injury, but it also can progress into chronic kidney disease. Chronic kidney disease is characterised by loss of function of the kidney tissues ...
Only when the amount of functioning kidney tissue is greatly diminished does one develop chronic kidney disease. Renal replacement therapy , in the form of dialysis or kidney transplantation , is indicated when the glomerular filtration rate has fallen very low or if the renal dysfunction leads to severe symptoms.
This stage accounts for 17% of kidney cancers and 69% of people are expected to live 5 years with this progression of kidney cancer. •Stage 4, the kidney tumour has spread to a distant organ or lymph node. 16% of kidney cancers are progressed to this stage and of those people, 12% of them are expected to live 5 years. [4]
The severity of chronic kidney disease (CKD) is described by six stages; the most severe three are defined by the MDRD-eGFR value, and first three also depend on whether there is other evidence of kidney disease (e.g., proteinuria): 0) Normal kidney function – GFR above 90 mL/min/1.73 m 2 and no proteinuria
Schematic of semipermeable membrane during hemodialysis, where blood is red, dialysing fluid is blue, and the membrane is yellow. Kidney dialysis (from Greek διάλυσις, dialysis, 'dissolution'; from διά, dia, 'through', and λύσις, lysis, 'loosening or splitting') is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer ...
The growth can be a result of increased cell size (compensatory hypertrophy) or an increase in cell division (compensatory hyperplasia) or both. [3] For instance, if one kidney is surgically removed, the cells of the other kidney divide at an increased rate. [1] Eventually, the remaining kidney can grow until its mass approaches the combined ...