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Fatal insomnia is an extremely rare neurodegenerative prion disease that results in trouble sleeping as its hallmark symptom. [2] The majority of cases are familial (fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically (sporadic fatal insomnia [sFI]).
A complete absence of sleep over a long period is not frequent in humans (unless they have fatal insomnia or specific issues caused by surgery); it appears that brief microsleeps cannot be avoided. [12] Long-term total sleep deprivation has caused death in lab animals. [13]
NREM, stage 3: deeper sleep. Known as slow-wave sleep or stage 3 non-REM sleep, this is the deepest stage of sleep and the hardest to wake up from. Brain activity slows down, muscles and bones ...
30 seconds of N3 – deep sleep. NREM Stage 3 (N3 – 15–25% of total sleep in adults): Formerly divided into stages 3 and 4, this stage is called slow-wave sleep (SWS) or deep sleep. SWS is initiated in the preoptic area and consists of delta activity, high amplitude waves at less than 3.5 Hz. The sleeper is less responsive to the ...
Early morning awakening is an awakening occurring earlier (more than 30 minutes) than desired with an inability to go back to sleep, and before total sleep time reaches 6.5 hours. Early morning awakening is often a characteristic of depression. [26] Anxiety symptoms may well lead to insomnia.
Randy Gardner (born c. 1946) is an American man from San Diego, California, who once held the record for the longest amount of time a human has gone without sleep.In December 1963/January 1964, 17-year-old Gardner stayed awake for 11 days and 24 minutes (264.4 hours), breaking the previous record of 260 hours held by Tom Rounds.
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Adolescent sleep phase delay "is present both across cultures and across mammalian species" and "it seems to be related to pubertal stage rather than age." [65] As a result, diagnosable DSPD is much more prevalent among adolescents. with estimates ranging from 3.4% to 8.4% among high school students. [66]