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Cevimeline (trade name Evoxac) is a synthetic analog of the natural alkaloid muscarine with a particular agonistic effect on M 1 and M 3 receptors. It is used in the treatment of dry mouth and Sjögren's syndrome .
Sjögren's syndrome is associated with a number of other medical conditions, many of which are autoimmune or rheumatic disorders, such as celiac disease, [24] [25] fibromyalgia, systemic lupus erythematosus (lupus), autoimmune thyroiditis, multiple sclerosis and spondyloarthropathy, [26] and several malignancies, principally non-Hodgkin lymphoma.
T2-weighted MRI images of a 25-year-old male with Sjögren–Larsson syndrome revealing dysmyelination in the deep periventricular white matter and reduced brain volume in the frontal lobe. Dry and scaly skin similar to all other ichtyosiforms (types of ichthyosis). Neurological problems – this can often cause mild paralysis in the legs
When there is proof of an autoimmune disease, but the disease does not correspond to any specific autoimmune disease (such as systemic lupus erythematosus (SLE), scleroderma, [2] mixed connective tissue disease, Sjögren syndrome, systemic sclerosis, polymyositis, dermatomyositis, or rheumatoid arthritis), it will be
Ianalumab (INN; [1] development code VAY736) is a monoclonal antibody that is being investigated for autoimmune hepatitis, multiple sclerosis, pemphigus vulgaris, rheumatoid arthritis, Sjogren's disease, Immune thrombocytopenic purpura and systemic lupus erythematosus.
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate. Anti-SSA autoantibodies (anti–Sjögren's-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with ...
In addition, tirabrutinib is in clinical development by Ono Pharmaceutical and Gilead Sciences [3] in the United States, Europe, and Japan for autoimmune disorders, chronic lymphocytic leukemia, B cell lymphoma, Sjogren's syndrome, pemphigus, and rheumatoid arthritis. [1] Tirabrutinib is an irreversible inhibitor of Bruton's tyrosine kinase. [4]
Sjögren syndrome, an autoimmune diseases named after Swedish ophthalmologist Henrik Sjögren; Sjögren–Larsson syndrome, an autosomal recessive form of ichthyosis apparent at birth; Marinesco–Sjögren syndrome, a syndrome consisting of cerebellar ataxia, mental retardation, congenital cataracts; Rabén & Sjögren, a book publishing company ...
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