Search results
Results from the WOW.Com Content Network
Enterochelin is a depsipeptide that is an iron-transporter. [5]Several depsipeptides have been found to exhibit anti-cancer properties. [6]A depsipeptide enzyme inhibitor includes romidepsin, a member of the bicyclic peptide class, a known histone deacetylase inhibitors (HDACi).
Acyldepsipeptide or cyclic acyldepsipeptide (ADEP) is a class of potential antibiotics first isolated from bacteria and act by deregulating the ClpP protease.Natural ADEPs were originally found as products of aerobic fermentation in Streptomyces hawaiiensis, A54556A and B, [1] and in the culture broth of Streptomyces species, enopeptin A and B. [2] ADEPs are of great interest in drug ...
α-Amanitin Bacitracin Ciclosporin. Cyclic peptides are polypeptide chains which contain a circular sequence of bonds. [1] This can be through a connection between the amino and carboxyl ends of the peptide, for example in cyclosporin; a connection between the amino end and a side chain, for example in bacitracin; the carboxyl end and a side chain, for example in colistin; or two side chains ...
The biosynthesis of depsipeptide Didemnin is governed by a hybrid non-ribosomal peptide synthetase-polyketide synthetase (NRPS-PKS) pathway. The didemnin mega-synthetase consists of 10 proteins, of which 8 NRPS and 2 PKS, covering 13 modules in total.
Retosiban [6] is a cyclic dipeptide being investigated as an oral drug. Diketopiperazines are a special class of dipeptides, which are cyclic. They form as side products in peptide synthesis. Many have been produced from non-canonical amino acids. [7]
Plitidepsin is a cyclic depsipeptide, meaning it is a cyclic peptide in which there is one or more ester bond in place of one or more of a peptide bond. Its chemical structure is very close to that of didemnin B, the only difference being that the lactate residue in didemnin B is present in the oxidized pyruvate version.
There are numerous types of peptides that have been classified according to their sources and functions. According to the Handbook of Biologically Active Peptides, some groups of peptides include plant peptides, bacterial/antibiotic peptides, fungal peptides, invertebrate peptides, amphibian/skin peptides, venom peptides, cancer/anticancer peptides, vaccine peptides, immune/inflammatory ...
They are mostly ampicillin derivatives in which the amino acid side chain has been converted to a variety of cyclic ureas. It is speculated that the added side chain mimics a longer segment of the peptidoglycan chain, more than ampicillin , and thus would bind more easily to the penicillin-binding proteins .