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Anemia (also spelled anaemia in British English) is a blood disorder in which the blood has a reduced ability to carry oxygen.This can be due to a lower than normal number of red blood cells, a reduction in the amount of hemoglobin available for oxygen transport, or abnormalities in hemoglobin that impair its function.
Pernicious anemia as described in 1849 by Addison is now also known as Addison-Biermer disease. It is a type of megaloblastic anemia, in which a lack of intrinsic factor causes absorption of vitamin B 12 to be impaired. It is caused by a lack of parietal cells in the stomach. [13]
Anemia is often discovered by routine blood tests. A sufficiently low hemoglobin by definition makes the diagnosis of anemia, and a low hematocrit value is also characteristic of anemia. Further studies will be undertaken to determine the anemia's cause.
Pernicious anemia is a disease where not enough red blood cells are produced due to a deficiency ... the much more dramatic response might not have been discovered then.
Before iron deficiency anemia sets in, “the body will do everything it can to retain the right number of red blood cells. So, it will deplete the storage iron before it depletes the red blood ...
Vitamin B 12 was discovered as a result of pernicious anemia, an autoimmune disorder in which the blood has a lower than normal number of red blood cells, due to a deficiency of vitamin B 12. [ 5 ] [ 16 ] The ability to absorb the vitamin declines with age, especially in people over 60.
In 1825, Johann Friedrich Engelhart discovered that the ratio of iron to protein is identical in the hemoglobins of several species. [ 16 ] [ 17 ] From the known atomic mass of iron, he calculated the molecular mass of hemoglobin to n × 16000 ( n =number of iron atoms per hemoglobin molecule, now known to be 4), the first determination of a ...
Iron deficiency, or sideropenia, is the state in which a body lacks enough iron to supply its needs. Iron is present in all cells in the human body and has several vital functions, such as carrying oxygen to the tissues from the lungs as a key component of the hemoglobin protein, acting as a transport medium for electrons within the cells in the form of cytochromes, and facilitating oxygen ...