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Piperidine is widely used to convert ketones to enamines. [23] Enamines derived from piperidine are substrates in the Stork enamine alkylation reaction. [24] Upon treatment with calcium hypochlorite, piperidine converts to N-chloropiperidine, a chloramine with the formula C 5 H 10 NCl.
N-Chloropiperidine is the organic compound with the formula C 5 H 10 NCl. A colorless liquid, it is a rare example of an organic chloramine, i.e. a compound with an N-Cl bond.It is prepared by treatment of piperidine with calcium hypochlorite.
In 1878, the structure of piperidine was still unknown, and A. W. Hofmann believed it unsaturated. [2] Following standard analytical technique, Hofmann added hydrogen chloride or bromine to it in an attempt to induce hydrohalogenation.
Morpholine undergoes most chemical reactions typical for other secondary amines, though the presence of the ether oxygen withdraws electron density from the nitrogen, rendering it less nucleophilic (and less basic) than structurally similar secondary amines such as piperidine. For this reason, it forms a stable chloramine. [10]
N-Chloropiperidine is a rare example of an organic chloramine. [5] Chloramine-T is often referred to as a chloramine, but it is really a salt (CH 3 C 6 H 4 SO 2 NClNa) derived from a chloramine. [6] Organic chloramines feature the NCl functional group attached to an organic substituent.
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Piperidine, a cyclic six-membered amine that results from hydrolysis of piperine; Piperic acid, the carboxylic acid also derived from hydrolysis of piperine; Capsaicin, the active piquant chemical in chili peppers; Allyl isothiocyanate, the active piquant chemical in mustard, radishes, horseradish, and wasabi
It can be viewed as a derivative of piperidine. 4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs. Substituted and dehydro derivatives of 4-piperidinone are intermediates in alkaloid syntheses. [1] The N-protonated derivative is typically isolated as the hydrate (HO) 2 C(CH 2) 4 NH + 2. [2]