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Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels. [1] Symptoms may include chest pain, shortness of breath, leg pain, problems speaking, or problems moving parts of the body. [1] As clotting factors and platelets are used up, bleeding may occur. [1]
It is characterized by overwhelming bacterial infection meningococcemia leading to massive blood invasion, organ failure, coma, low blood pressure and shock, disseminated intravascular coagulation (DIC) with widespread purpura, rapidly developing adrenocortical insufficiency and death.
Hemolysis, shock, ischemia, acute respiratory distress syndrome, disseminated intravascular coagulation, [1] and acute renal failure. [2] Usual onset: Hours to months (various types of hypersensitivities reactions)of the initial drug exposure. [1] Causes: Antimicrobials, nonsteroidal anti-inflammatory drugs, antineoplastic drugs, and other ...
People with AHTR are managed with supportive care, which may include diuretics, blood pressure support, and treatment of disseminated intravascular coagulation (with fresh frozen plasma, cryoprecipitate, and platelet transfusion). [6] The use of steroids, intravenous immune-globulins or plasma exchange is not supported by evidence. [6]
In diseases such as hemolytic uremic syndrome, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and malignant hypertension, the endothelial layer of small vessels is damaged with resulting fibrin deposition and platelet aggregation. As red blood cells travel through these damaged vessels, they are fragmented ...
The onset of widespread purpura, known as purpura fulminans, is a dangerous condition associated with disseminated intravascular coagulation (DIC). Determining the root cause of DIC is crucial for treatment. In severe opportunistic infections, retiform purpura can also emerge.
Disseminated intravascular coagulation may occur in a significant number of patients with presentation of various degrees of thrombin generation, followed by decreased fibrinogen and increased fibrinolysis. [citation needed] Spontaneous tumor lysis syndrome is present in approximately 10 percent of patients with leukostasis.
Purpura fulminans with disseminated intravascular coagulation should be urgently treated with fresh frozen plasma (10–20 mL/kg every 8–12 hours) and/or protein C concentrate to replace pro-coagulant and anticoagulant plasma proteins that have been depleted by the disseminated intravascular coagulation process. [2] [3] [4] [7]