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The continuous stirred-tank reactor (CSTR), also known as vat-or backmix reactor, mixed flow reactor (MFR), or a continuous-flow stirred-tank reactor (CFSTR), is a common model for a chemical reactor in chemical engineering and environmental engineering. A CSTR often refers to a model used to estimate the key unit operation variables when using ...
General structure of a continuous stirred-tank type bioreactor. On the basis of mode of operation, a bioreactor may be classified as batch, fed batch or continuous (e.g. a continuous stirred-tank reactor model). An example of a continuous bioreactor is the chemostat. [citation needed]
A chemostat (from chemical environment is static) is a bioreactor to which fresh medium is continuously added, while culture liquid containing left over nutrients, metabolic end products and microorganisms is continuously removed at the same rate to keep the culture volume constant.
Stirred tank bioreactors are systems further developed to two compartment systems to provide a fundamental structure for Scale down bioreactors. Two commonly used developed systems are cells which are circulated between either two stirred tank reactors (STR–STR), or from a STR through a plug flow reactor (STR–PFR).
The most familiar form of continuous reactor of this type is the continuously stirred tank reactor (CSTR). This is essentially a batch reactor used in a continuous flow. The disadvantage with a single stage CSTR is that it can be relatively wasteful on product during start up and shutdown.
The behavior of a CSTR is often approximated or modeled by that of a Continuous Ideally Stirred-Tank Reactor (CISTR). All calculations performed with CISTRs assume perfect mixing. If the residence time is 5-10 times the mixing time, this approximation is considered valid for engineering purposes.
Each plug of differential volume is considered as a separate entity, effectively an infinitesimally small continuous stirred tank reactor, limiting to zero volume. As it flows down the tubular PFR, the residence time ( τ {\displaystyle \tau } ) of the plug is a function of its position in the reactor.
Stirred tank bioreactors are used for the biooxidation of gold. [16] While stirred tanks have been used to bioleach cobalt for copper mine tailings, [18] these are costly systems that can reach sizes of >1300m 3 meaning that they are almost exclusively used for very high value minerals like gold. [16] Illustration of the process of uranium heap ...
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