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The PDUFA date thus serves as a 'best estimate' of when a decision on a New Drug Application or a Biologics License Application would be forthcoming. This response may be a decision to approve the application or a Complete Response Letter (CRL). The PDUFA date may be extended by the Food and Drug Administration in certain circumstances. [6]
α-Pyrrolidinohexiophenone is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain.Regarding the potency of alpha-PHP in the brain, chemist Michael H. Baumann of the Designer Drug Research Unit (established by Baumann [8]) of the National Institute on Drug Abuse stated: "alpha-PHP might be even more potent than alpha-PVP"; this statement is based on laboratory ...
A case of a "fatal acute intoxication caused by MDPHP" in a 48 year old male was reported in February 2022 by physicians at an Italian hospital. [11] Another case has been reported, involving a 30-years-old male cocaine consumer, found dead on July 20th, 2023, in Florence, Italy; MDPHP and alpha-PHP were the only psychoactive substance found.
The first development release of Zend Framework 2.0 was released on August 6, 2010. [29] Changes made in this release were the removal of require_once statements, migration to PHP 5.3 namespaces, a refactored test suite, a rewritten Zend\Session, and the addition of the new Zend\Stdlib. The second development release was on November 3, 2010. [30]
New default templates based on Bootstrap; added support for PostgreSQL as a database backend; remove support for PHP 5.2. Notes: The original plan was to release this version in July 2012; however, the January/July release schedule was uncomfortable for volunteers, and the schedule was changed to September/March releases. [85]
Release date Support PHP version End of maintenance Notes 1.0 January 2007 Three years ≥ 5.0 January 2010 1.1 June 2008 One year ≥ 5.1 June 2009 Security-related patches were applied until June 2010 1.2 December 2008 One year ≥ 5.2 November 2009 1.3 November 2009 One year ≥ 5.2.4 November 2010 1.4 November 2009 Three years ≥ 5.2.4
Release notes detail the corrections, changes or enhancements (functional or non-functional) made to the service or product the company provides.[7] [8] [9]They might also be provided as an artifact accompanying the deliverables for System Testing and System Integration Testing and other managed environments especially with reference to an information technology organization.
Composer is an application-level dependency manager for the PHP programming language that provides a standard format for managing dependencies of PHP software and required libraries. It was developed by Nils Adermann and Jordi Boggiano, who continue to manage the project. They began development in April 2011 and first released it on March 1 ...