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SSRIs, including citalopram, can increase the risk of bleeding, especially when coupled with aspirin, NSAIDs, warfarin, or other anticoagulants. [37] Taking citalopram with omeprazole may cause higher blood levels of citalopram. This is a potentially dangerous interaction, so dosage adjustments may be needed or alternatives may be prescribed.
Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [22] The effect sizes ( Cohen's d ) of SSRIs in terms of improvement on the Liebowitz social anxiety scale in individual published trials of the drugs for social anxiety disorder have ranged from –0. ...
Unlike its counterpart, the Occupational Safety and Health Administration, NIOSH's authority under the Occupational Safety and Health Act [29 CFR § 671] is to "develop recommendations for health and safety standards", to "develop information on safe levels of exposure to toxic materials and harmful physical agents and substances", and to "conduct research on new safety and health problems".
The safety of these medications has not been well studied. [135] Due to the lack of high quality studies, preliminary nature of studies showing effectiveness, the lack of adequate study on their safety, and reports of eosinophilia–myalgia syndrome from contaminated tryptophan in 1989 and 1990, [ 114 ] the use of tryptophan and 5-HTP is not ...
Escitalopram is the (S)-enantiomer of citalopram (which exists as a racemate), hence the name es-citalopram. [9] Escitalopram was approved for medical use in the United States in 2002. [9] Escitalopram is rarely replaced by twice the dose of citalopram; escitalopram is safer and more effective. [11]
Didesmethylescitalopram is an active metabolite of the antidepressant escitalopram, the S-enantiomer of citalopram. Like citalopram and escitalopram, didesmethyl(es)citalopram functions as a selective serotonin reuptake inhibitor (SSRI), and is responsible for some of its parents' therapeutic benefits .
Desmethylcitalopram is an active metabolite of the antidepressant drugs citalopram and escitalopram (the S-enantiomer, which would be called desmethylescitalopram). [ 1 ] [ 2 ] Like citalopram and escitalopram, desmethylcitalopram functions as a selective serotonin reuptake inhibitor (SSRI), and is responsible for some of its parents ...
[138] [139] The main statutory legislation on health and safety in the jurisdiction of the Department of Employment and Labour is the OHS Act or OHSA (Act No. 85 of 1993: Occupational Health and Safety Act, as amended by the Occupational Health and Safety Amendment Act, No. 181 of 1993). [138]