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Primary pellagra is due to a diet that does not contain enough niacin and tryptophan. [1] Secondary pellagra is due to a poor ability to use the niacin within the diet. [1] This can occur as a result of alcoholism, long-term diarrhea, carcinoid syndrome, Hartnup disease, and a number of medications such as isoniazid. [1]
A man with pellagra, which is caused by a chronic lack of vitamin B 3 in the diet. Severe deficiency of niacin in the diet causes the disease pellagra, characterized by diarrhea, sun-sensitive dermatitis involving hyperpigmentation and thickening of the skin (see image), inflammation of the mouth and tongue, delirium, dementia, and if left untreated, death. [7]
A disease that was characterized by dermatitis of sunlight-exposed skin was described in Spain in 1735 by Gaspar Casal. He attributed the cause to poor diet. [47] In northern Italy it was named pellagra from the Lombard language (agra = holly-like or serum-like; pell = skin). [48] [49] In time, the disease was more closely linked specifically ...
Pellagra, a similar condition, is also caused by low nicotinamide; this disorder results in dermatitis, diarrhea, and dementia. [citation needed] Hartnup disease is a disorder of amino acid transport in the intestine and kidneys; otherwise, the intestine and kidneys function normally, and the effects of the disease occur mainly in the brain and ...
People who adhere to a plant-based diet may also experience weight loss, reduced risk of heart disease, and improved cholesterol and blood pressure levels, per a 2020 study in Clinical Nutrition.
Common, most foods do not contain vitamin D, indicating that a deficiency will occur unless people get sunlight exposure or eat manufactured foods purposely fortified with vitamin D. Vitamin D deficiency is a known cause of rickets, and has been linked to numerous other health problems. [46] [47] Vitamin E deficiency
Unfortunately, after the study, the funding for more nutritious food dried up and the pellagra rates in the orphanages and asylum returned to pre-study levels. [1] Goldberger's next objective was to confirm the relationship between poor diet and pellagra. To do this, he met with Earl L. Brewer, the governor of Mississippi, in 1915. He requested ...
The diet in the tropics tended [when?] to depend more heavily on plant foods, while the diet at higher latitudes tended more towards animal products. Analyses of postcranial and cranial remains of humans and animals from the Neolithic, along with detailed bone-modification studies, have shown that cannibalism also occurred among prehistoric humans.