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Frovatriptan, sold under the brand name Frova, is a triptan drug developed by Vernalis for the treatment of migraine headaches [1] and for short term prevention of menstrual migraine. [2] The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.
Sumatriptan [4] binds to 5-HT 1D receptors, zolmitriptan, [5] rizatriptan, [6] naratriptan, [7] almotriptan, [8] and frovatriptan [9] binds to 5-HT 1B/1D and eletriptan [10] binds to 5-HT 1B/1D/1F receptors. Triptans are believed to exert their effects through vasoconstriction, leading to reduced carotid arterial circulation without affecting ...
Frovatriptan: Frova Vernalis 5-HT 1B/D: 8.4 24–30 2–4 26 CYP1A2: 2.5 Zolmitriptan is different from the other triptans because it is converted to an active N ...
Lasmiditan is a serotonin receptor agonist that, like the unsuccessful LY-334,370, selectively binds to the 5-HT 1F receptor subtype. A number of triptans have been shown to act on this subtype as well, but only after their affinity for 5-HT 1B and 5-HT 1D has been made responsible for their anti-migraine activity.
Sumatriptan/naproxen, sold under the brand name Treximet among others, is a fixed-dose combination medication used to treat migraines. [2] It is taken by mouth. [2] It contains sumatriptan, as the succinate, a serotonin 5-hydroxytryptamine (5-HT) 1b/1d receptor agonist (); and naproxen as the sodium salt, a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs).
Sumatriptan, sold under the brand name Imitrex among others, is a medication used to treat migraine headaches and cluster headaches. [1] It is taken orally, intranasally, or by subcutaneous injection. [2]
A meta-analysis of 53 clinical trials has shown that all triptans are effective for treating migraine at marketed doses and that naratriptan, although less effective than sumatriptan and rizatriptan was more effective than placebo in reducing migraine symptoms at two hours [3] and efficacy was demonstrated in almost two thirds of subjects after four hours of treatment.
As with other triptans, almotriptan should not be used in patients with a history, symptoms or signs of ischaemic heart disease (myocardial infarction, angina pectoris, documented silent ischaemia, Prinzmetal's angina) or severe hypertension and uncontrolled mild or moderate hypertension.
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