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Drugs that target ALK are referred to as ALK inhibitors. ALK is expressed on the surface of neuroblastoma tumor cells, making it easily accessible as a target for cancer treatment. [1] In neuroblastoma patients who do not possess a mutated form of ALK, targeting the non-mutated form of ALK on a tumor cell can also be beneficial. [1]
In high-risk disease, chances of long-term survival, however, are less than 40%, despite aggressive treatment. [5] Neuroblastoma is the most common cancer in babies and the third-most common cancer in children after leukemia and brain cancer. [5] About one in every 7,000 children is affected at some time. [2]
Metastases of this cancer type is not usually reported, and the treatment for this disease often includes full tumor resection along with radiotherapy and chemotherapy. Immunotherapy, as well as integrin signaling pathways inhibitors are also useful for its treatment, and the prognosis depends on the localization of the tumor, the degree of ...
The approach to management of a CNS PNET is first to obtain detailed imaging through MRI, as well as additional scans of the patient's body (X-ray, CT, PET, even bone marrow biopsies) to look for metastasis or other associated malignancies. The tumor will then need to be biopsied to confirm the diagnosis.
Almost all patients (80-90%) show improvement with this treatment and the relapse rate appears to be about 20%. [16] A more detailed summary of current treatment options can be found at Treatment Options. The following medications should probably be avoided: Midazolam - Can cause irritability. Melatonin - Is known to stimulate the immune system.
This is an accepted version of this page This is the latest accepted revision, reviewed on 23 January 2025. Neoplasm in the brain Medical condition Brain tumor Other names Intracranial neoplasm, brain tumour, brain cancer Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging Specialty Neurosurgery, neuro-oncology Symptoms Vary depending on the ...
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The Neuroblastoma Children's Cancer Alliance UK, commonly referred to as NCCA UK, is a UK charity that helps children and families affected by neuroblastoma, a type of childhood cancer. The charity helps families by helping them to access and fundraise for their child's treatment abroad when no treatment is available in the UK, offering support ...