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  2. Nikolsky's sign - Wikipedia

    en.wikipedia.org/wiki/Nikolsky's_sign

    The Nikolsky sign is dislodgement of intact superficial epidermis by a shearing force, indicating a plane of cleavage in the skin epidermal-epidermal junctions (e.g., desmosomes). The histological picture involves thinner, weaker attachments of the skin lesion itself to the normal skin – resulting in easier dislodgement.

  3. Staphylococcal scalded skin syndrome - Wikipedia

    en.wikipedia.org/wiki/Staphylococcal_scalded...

    SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).

  4. List of eponymous medical signs - Wikipedia

    en.wikipedia.org/.../List_of_eponymous_medical_signs

    Müller's sign at Who Named It? visible pulsation or bobbing of uvula: Murphy's punch sign: John B. Murphy: urology: perinephric abscess: Murphy's punch at Who Named It? punch tenderness at the costovertebral angle Murphy's sign: John B. Murphy: surgery: cholecystitis: Murphy's sign at Who Named It? hesitation on inspiration while gall bladder ...

  5. Stevens–Johnson syndrome - Wikipedia

    en.wikipedia.org/wiki/Stevens–Johnson_syndrome

    The diagnosis is based on involvement of less than 10% of the skin. [2] It is known as TEN when more than 30% of the skin is involved and an intermediate form with 10 to 30% involvement. [3] A positive Nikolsky's sign is helpful in the diagnosis of SJS and TEN. [9] A skin biopsy is helpful, but not required, to establish a diagnosis of SJS and ...

  6. Mucous membrane pemphigoid - Wikipedia

    en.wikipedia.org/wiki/Mucous_membrane_pemphigoid

    Diagnostic techniques: antibodies (IgG) precipitate complement (C3) in the lamina lucida of the basement membrane. Circulating auto-antibodies to BP-1 antigen (located in hemidesmosome). 50% have BP-2. Positive Nikolsky sign. IgG, C3 deposition at BM creating smooth line in immunofluorescent analysis.

  7. Toxic epidermal necrolysis - Wikipedia

    en.wikipedia.org/wiki/Toxic_epidermal_necrolysis

    Diagnosis is based on a skin biopsy and involvement of more than 30% of the skin. [3] TEN is a type of severe cutaneous adverse reactions (SCARs), together with SJS, a SJS/TEN, and drug reaction with eosinophilia and systemic symptoms. [5] It is called SJS when less than 10% of the skin is involved and an intermediate form with 10 to 30% ...

  8. Asboe-Hansen sign - Wikipedia

    en.wikipedia.org/wiki/Asboe-Hansen_sign

    [2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions. [ 4 ] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.

  9. Nikolsky - Wikipedia

    en.wikipedia.org/wiki/Nikolsky

    Nikolsky (surname), including a list of people with the name; Nikolski Air Station, an airport located in Nikolski, Alaska; Nikolskoye Airport, an airport in Kamchatka Krai, Russia; Nikolski, a novel by Canadian writer Nicolas Dickner; Nikolsky Old Believer Monastery, a monastery near Preobrazhenskoye Cemetery in Moscow, Russia