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In the field of enzymology, a betaine-homocysteine S-methyltransferase also known as betaine-homocysteine methyltransferase (BHMT) is a zinc metallo-enzyme that catalyzes the transfer of a methyl group from trimethylglycine and a hydrogen ion from homocysteine to produce dimethylglycine and methionine respectively: [2]
In enzymology, a homocysteine S-methyltransferase (EC 2.1.1.10) is an enzyme that catalyzes the chemical reaction. S-methylmethionine + L-homocysteine 2 L-methionine. Thus, the two substrates of this enzyme are S-methylmethionine and L-homocysteine, and it produces 2 molecules of L-methionine.
A second pathway, which is usually restricted to liver and kidney in most mammals, involves betaine-homocysteine methyltransferase (BHMT) and requires trimethylglycine as a cofactor. [ 2 ] DNA processing and epigenetics
Betaine—homocysteine S-methyltransferase From an initialism : This is a redirect from an initialism to a related topic, such as the expansion of the initialism. Use {{ R from acronym }} instead for abbreviations that are pronounced as words, such as NATO and RADAR.
Pages for logged out editors learn more. Contributions; Talk; Betaine-homocysteine methyltransferase
EC 2.1.1.376: glycine betaine—corrinoid protein Co-methyltransferase EC 2.1.1.377 : [methyl-Co(III) glycine betaine-specific corrinoid protein]—coenzyme M methyltransferase EC 2.1.1.378 : [methyl-Co(III) glycine betaine-specific corrinoid protein]—tetrahydrofolate methyltransferase
The enzyme from Escherichia coli consists of two alpha8-beta8 (TIM) barrels positioned face to face and thought to have evolved by gene duplication. [1] The active site lies between the tops of the two barrels, the N-terminal barrel binds 5-methyltetrahydropteroyltri-L-glutamic acid and the C-terminal barrel binds homocysteine.
S-adenosyl-L-methionine + DNA adenine S-adenosyl-L-homocysteine + DNA 6-methylaminopurine m6A was primarily found in prokaryotes until 2015 when it was also identified in some eukaryotes. m6A methyltransferases methylate the amino group in DNA at C-6 position specifically to prevent the host system to digest own genome through restriction enzymes.