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Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [2] It is a reasonable initial treatment for high blood pressure. [2]
Rilmazafone [1] (リスミー, Rhythmy, previously known as 450191-S) is a water-soluble prodrug developed in Japan. [2] Inside the human body, rilmazafone is converted into several benzodiazepine metabolites that have sedative and hypnotic effects.
3-Amino-1,2,4-triazole (3-AT) is a heterocyclic organic compound that consists of 1,2,4-triazole with an amino group as a substituent. 3-AT is a competitive inhibitor of the product of the HIS3 gene, imidazoleglycerol-phosphate dehydratase. [3] [4] Imidazoleglycerol-phosphate dehydratase is an enzyme catalyzing the sixth step of histidine ...
Anamorelin (developmental code names ONO-7643, RC-1291, ST-1291), also known as anamorelin hydrochloride (USAN, JAN), is a non-peptide, orally-active, centrally-penetrant, selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) with appetite-enhancing and anabolic effects which is under development by Helsinn Healthcare SA for the treatment of cancer cachexia and anorexia.
Clidinium inhibits muscarinic acetylcholine receptors on smooth muscles, secretory glands, and in the central nervous system to relax smooth muscle and decrease biliary tract secretions. [4] It is said to be a selective muscarinic acetylcholine M 3 receptor antagonist .
Ubenimex (), also known more commonly as bestatin, is a competitive, reversible protease inhibitor.It is an inhibitor of arginyl aminopeptidase (aminopeptidase B), [3] leukotriene A 4 hydrolase (a zinc metalloprotease that displays both epoxide hydrolase and aminopeptidase activities), [4] alanyl aminopeptidase (aminopeptidase M/N), [5] leucyl/cystinyl aminopeptidase (oxytocinase ...
Cefprozil synthesis: [8] [9] [10] Separation of isomers: [11] Displacement of the allylic chloride in intermediate ( 1 ) with triphenylphosphine gives the phosphonium salt ( 2 ). This functionality is then converted to its ylide ; condensation with acetaldehyde then leads to the vinyl derivative ( 3 ); deprotection then gives cefprozil.
[4] [5] [6] A dose of 20 mg/day results in aspermia due to reversible paralyzing effects on the vas deferens, ampulla, and ejaculatory ducts. [7] Due to these actions, phenoxybenzamine is also useful for the treatment of premature ejaculation in men.